| Reaction Details |
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 | Report a problem with these data |
| Target | Ectonucleoside triphosphate diphosphohydrolase 1 |
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| Ligand | BDBM50227019 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2033475 (CHEMBL4687633) |
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| Ki | 15700±n/a nM |
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| Citation |  Jeffrey, JL; Lawson, KV; Powers, JP Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39. J Med Chem63:13444-13465 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ectonucleoside triphosphate diphosphohydrolase 1 |
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| Name: | Ectonucleoside triphosphate diphosphohydrolase 1 |
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| Synonyms: | ATPDase | CD_antigen=CD39 | Cd39 | ENTP1_RAT | Ecto-ATP diphosphohydrolase | Ecto-apyrase | Entpd1 | Lymphoid cell activation antigen | NTPDase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57412.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_463990 |
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| Residue: | 511 |
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| Sequence: | MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTHNKPLPENVKYGIVLDAGSSHT
NLYIYKWPAEKENDTGVVQLLEECQVKGPGISKYAQKTDEIAAYLAECMKMSTERIPASK
QHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYPFDFQGAKIITGQEEGAYGWI
TINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTFVPLNQTLEAPETSLQFRL
YGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPC
TKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNNSHCPYSQCAFNGVFLPPLQGSFGAFS
AFYFVMDFFKKMANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYI
LSLLLQGYNFTGTSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYIS
LMVLFSLVLVAMVITGLFIFSKPSYFWKEAV
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| BDBM50227019 |
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| n/a |
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| Name | BDBM50227019 |
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| Synonyms: | CHEMBL271673 | sodium 1-amino-4-(4-chlorophenylamino)-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate |
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| Type | Small organic molecule |
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| Emp. Form. | C20H12ClN2O5S |
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| Mol. Mass. | 427.838 |
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| SMILES | Nc1c(cc(Nc2ccc(Cl)cc2)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O |
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| Structure | 
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