Reaction Details |
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Target | Falcilysin |
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Ligand | BDBM50461717 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2034041 (CHEMBL4688199) |
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Ki | 3000±n/a nM |
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Citation | Kahlon, G; Lira, R; Masvlov, N; Pompa, E; Brar, N; Eagon, S; Anderson, MO; Andaya, A; Chance, JP; Fejzic, H; Keniston, A; Huynh, N; Celis, N; Vidal, B; Trieu, N; Rodriguez, P; Mallari, JP Structure guided development of potent piperazine-derived hydroxamic acid inhibitors targeting falcilysin. Bioorg Med Chem Lett32:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Falcilysin |
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Name: | Falcilysin |
Synonyms: | 3.4.24.- | Falcilysin |
Type: | PROTEIN |
Mol. Mass.: | 138868.64 |
Organism: | Plasmodium falciparum (isolate 3D7) |
Description: | ChEMBL_118121 |
Residue: | 1193 |
Sequence: | MNLTKLMKVIGYINIITNCVQSFTNRADKKRYNVFAKSFINTINTNLYTFKAVMSKTPEW
IHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPLDVEQAFAFYVKTL
THSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLHTHLNAYTFNDRTVYMAGSMNNKD
FFNIMGVYMDSVFQPNVLENKYIFETEGWTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIV
YNEMKGALSSPLEDLYHEEMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKK
VKVFFFSKNNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDHSEE
KENLVSVAWLLNPKVDKTNNHNNNHSNNQSSENNGYSNGSHSSDLSLENPTDYFVLLIIN
NLLIHTPESVLYKALTDCGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHY
EVEDVIMNALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLNYNRD
PLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEGDENYAQEQENLEKQ
ELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEHLNKFPIISISDLNKKTLEVPVNVY
FTNINENNNIMETYNKLKTNEHMLKDNMDVFLKKYVLKNDKHNTNNNNNNNNNMDYSFTE
TKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELAYLNLFKTLILENKTNKRSSEDFV
ILREKNIGSMSANVALYSKDDHLNVTDKYNAQALFNLEMHVLSHKCNDALNIALEAVKES
DFSNKKKVIDILKRKINGMKTTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQE
QLELAENDFKTLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSYFEE
NDKYINDMQNKVNDPTVMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKPGE
YLDPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARDPNLEKTLATFRE
SAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELSKLSFLRLISNESEQDRVEFRKR
IMNTKKEDFYKFADLLESKVNEFEKNIVIITTKEKANEYIANVDGEFKKVLIE
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BDBM50461717 |
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n/a |
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Name | BDBM50461717 |
Synonyms: | CHEMBL4225532 |
Type | Small organic molecule |
Emp. Form. | C24H22BrN3O5S |
Mol. Mass. | 544.418 |
SMILES | ONC(=O)C1CN(CCN1S(=O)(=O)c1ccc(Br)cc1)C(=O)c1ccc(cc1)-c1ccccc1 |
Structure |
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