| Reaction Details |
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 | Report a problem with these data |
| Target | Falcilysin |
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| Ligand | BDBM50552273 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2034041 (CHEMBL4688199) |
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| Ki | 2600±n/a nM |
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| Citation |  Kahlon, G; Lira, R; Masvlov, N; Pompa, E; Brar, N; Eagon, S; Anderson, MO; Andaya, A; Chance, JP; Fejzic, H; Keniston, A; Huynh, N; Celis, N; Vidal, B; Trieu, N; Rodriguez, P; Mallari, JP Structure guided development of potent piperazine-derived hydroxamic acid inhibitors targeting falcilysin. Bioorg Med Chem Lett32:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Falcilysin |
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| Name: | Falcilysin |
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| Synonyms: | 3.4.24.- | Falcilysin |
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| Type: | PROTEIN |
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| Mol. Mass.: | 138868.64 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_118121 |
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| Residue: | 1193 |
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| Sequence: | MNLTKLMKVIGYINIITNCVQSFTNRADKKRYNVFAKSFINTINTNLYTFKAVMSKTPEW
IHEKSPKHNSYDIIEKRYNEEFKMTYTVYQHKKAKTQVISLGTNDPLDVEQAFAFYVKTL
THSGKGIPHILEHSVLSGSKNYNYKNSIGLLEKGTLHTHLNAYTFNDRTVYMAGSMNNKD
FFNIMGVYMDSVFQPNVLENKYIFETEGWTYEVEKLKEDEKGKAEIPQMKDYKVSFNGIV
YNEMKGALSSPLEDLYHEEMKYMFPDNVHSNNSGGDPKEITNLTYEEFKEFYYKNYNPKK
VKVFFFSKNNPTELLNFVDQYLGQLDYSKYRDDAVESVEYQTYKKGPFYIKKKYGDHSEE
KENLVSVAWLLNPKVDKTNNHNNNHSNNQSSENNGYSNGSHSSDLSLENPTDYFVLLIIN
NLLIHTPESVLYKALTDCGLGNNVIDRGLNDSLVQYIFSIGLKGIKRNNEKIKNFDKVHY
EVEDVIMNALKKVVKEGFNKSAVEASINNIEFILKEANLKTSKSIDFVFEMTSKLNYNRD
PLLIFEFEKYLNIVKNKIKNEPMYLEKFVEKHFINNAHRSVILLEGDENYAQEQENLEKQ
ELKKRIENFNEQEKEQVIKNFEELSKYKNAEESPEHLNKFPIISISDLNKKTLEVPVNVY
FTNINENNNIMETYNKLKTNEHMLKDNMDVFLKKYVLKNDKHNTNNNNNNNNNMDYSFTE
TKYEGNVPILVYEMPTTGIVYLQFVFSLDHLTVDELAYLNLFKTLILENKTNKRSSEDFV
ILREKNIGSMSANVALYSKDDHLNVTDKYNAQALFNLEMHVLSHKCNDALNIALEAVKES
DFSNKKKVIDILKRKINGMKTTFSEKGYAILMKYVKAHLNSKHYAHNIIYGYENYLKLQE
QLELAENDFKTLENILVRIRNKIFNKKNLMVSVTSDYGALKHLFVNSNESLKNLVSYFEE
NDKYINDMQNKVNDPTVMGWNEEIKSKKLFDEEKVKKEFFVLPTFVNSVSMSGILFKPGE
YLDPSFTVIVAALKNSYLWDTVRGLNGAYGVFADIEYDGSVVFLSARDPNLEKTLATFRE
SAKGLRKMADTMTENDLLRYIINTIGTIDKPRRGIELSKLSFLRLISNESEQDRVEFRKR
IMNTKKEDFYKFADLLESKVNEFEKNIVIITTKEKANEYIANVDGEFKKVLIE
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| BDBM50552273 |
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| n/a |
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| Name | BDBM50552273 |
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| Synonyms: | CHEMBL4763576 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24IN3O5S2 |
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| Mol. Mass. | 625.499 |
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| SMILES | CNC(=O)C1CN(CCN1S(=O)(=O)c1ccc(cc1)-c1ccccc1)S(=O)(=O)c1ccc(I)cc1 |
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| Structure | 
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