| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50552442 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2034380 (CHEMBL4688538) |
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| Ki | 794±n/a nM |
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| Citation |  Corrêa, MF; Balico-Silva, AL; Kiss, DJ; Fernandes, GAB; Maraschin, JC; Parreiras-E-Silva, LT; Varela, MT; Simões, SC; Bouvier, M; Keser?, GM; Costa-Neto, CM; Fernandes, JPS Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H Bioorg Med Chem30:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50552442 |
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| n/a |
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| Name | BDBM50552442 |
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| Synonyms: | CHEMBL4792753 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H19ClN2O |
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| Mol. Mass. | 266.766 |
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| SMILES | CN1CCN(CC2Cc3cc(Cl)ccc3O2)CC1 |
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| Structure | 
|
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