| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM50112079 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_225421 (CHEMBL845034) |
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| IC50 | 130±n/a nM |
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| Citation |  Hauel, NH; Nar, H; Priepke, H; Ries, U; Stassen, JM; Wienen, W Structure-based design of novel potent nonpeptide thrombin inhibitors. J Med Chem45:1757-66 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM50112079 |
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| n/a |
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| Name | BDBM50112079 |
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| Synonyms: | 4-[[2-(4-Carbamimidoyl-benzyl)-1-methyl-1H-benzoimidazol-5-yl]-(quinoline-8-sulfonyl)-amino]-butyric acid | CHEMBL299580 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28N6O4S |
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| Mol. Mass. | 556.635 |
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| SMILES | Cn1c(Cc2ccc(cc2)C(N)=N)nc2cc(ccc12)N(CCCC(O)=O)S(=O)(=O)c1cccc2cccnc12 |
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| Structure | 
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