Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50100452 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_87865 (CHEMBL697288) |
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IC50 | 4900±n/a nM |
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Citation | Mai, A; Massa, S; Ragno, R; Esposito, M; Sbardella, G; Nocca, G; Scatena, R; Jesacher, F; Loidl, P; Brosch, G Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation. J Med Chem45:1778-84 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | HD1 | HDAC1_MOUSE | Hdac1 | Histone deacetylase 1/2 |
Type: | Protein |
Mol. Mass.: | 55062.26 |
Organism: | Mus musculus (Mouse) |
Description: | O09106 |
Residue: | 482 |
Sequence: | MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEF
SDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50100452 |
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n/a |
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Name | BDBM50100452 |
Synonyms: | 3-((E)-4-Benzoyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-acrylamide | 3-(4-Benzoyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-acrylamide | CHEMBL13168 |
Type | Small organic molecule |
Emp. Form. | C15H14N2O3 |
Mol. Mass. | 270.2833 |
SMILES | Cn1cc(cc1\C=C\C(=O)NO)C(=O)c1ccccc1 |
Structure |
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