Reaction Details |
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Target | G-protein coupled bile acid receptor 1 |
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Ligand | BDBM50552647 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2035144 (CHEMBL4689302) |
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EC50 | 1.1±n/a nM |
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Citation | Zhao, S; Li, X; Wang, L; Peng, W; Ye, W; Li, W; Wang, YD; Chen, WD Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists. Bioorg Med Chem32:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G-protein coupled bile acid receptor 1 |
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Name: | G-protein coupled bile acid receptor 1 |
Synonyms: | BG37 | GPBAR1 | GPBAR_HUMAN | M-BAR | TGR5 | hBG37 | hGPCR19 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 35260.02 |
Organism: | Homo sapiens (Human) |
Description: | CHO cells transiently transfected with hTGR5. |
Residue: | 330 |
Sequence: | MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLA
GLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQP
PGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGA
AAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPY
VATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQ
GLWGRASRDSPGPSIAYHPSSQSSVDLDLN
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BDBM50552647 |
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n/a |
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Name | BDBM50552647 |
Synonyms: | CHEMBL4790044 |
Type | Small organic molecule |
Emp. Form. | C22H23FN4O |
Mol. Mass. | 378.4426 |
SMILES | C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(CC1)c1ccccc1F |r| |
Structure |
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