| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease 1 |
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| Ligand | BDBM50112508 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_213077 |
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| Ki | 91±n/a nM |
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| Citation |  Shaw, KJ; Guilford, WJ; Griedel, BD; Sakata, S; Trinh, L; Wu, S; Xu, W; Zhao, Z; Morrissey, MM Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity. Bioorg Med Chem Lett12:1311-4 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease 1 |
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| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
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| BDBM50112508 |
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| n/a |
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| Name | BDBM50112508 |
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| Synonyms: | 4'-{2-Ethyl-6-[1-(1-imino-ethyl)-piperidin-4-yloxy]-benzoimidazol-1-ylmethyl}-biphenyl-4-carboxamidine | CHEMBL25184 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34N6O |
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| Mol. Mass. | 494.6306 |
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| SMILES | CCc1nc2ccc(OC3CCN(CC3)C(C)=N)cc2n1Cc1ccc(cc1)-c1ccc(cc1)C(N)=N |
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| Structure | 
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