| Reaction Details |
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 | Report a problem with these data |
| Target | Furin |
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| Ligand | BDBM50552675 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2035313 (CHEMBL4689471) |
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| Ki | 0.114±n/a nM |
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| Citation |  Lam van, TV; Heindl, MR; Schlutt, C; Böttcher-Friebertshäuser, E; Bartenschlager, R; Klebe, G; Brandstetter, H; Dahms, SO; Steinmetzer, T The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. ACS Med Chem Lett12:426-432 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Furin |
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| Name: | Furin |
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| Synonyms: | FUR | FURIN | FURIN_HUMAN | Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA | PACE | PCSK3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86676.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09958 |
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| Residue: | 794 |
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| Sequence: | MELRPWLLWVVAATGTLVLLAADAQGQKVFTNTWAVRIPGGPAVANSVARKHGFLNLGQI
FGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQVQWLEQQVAKRRTKRDVYQEPTDPKFPQ
QWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRKTVTACLGEPNH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPVPPESSGCKTLTSSQACVVCE
EGFSLHQKSCVQHCPPGFAPQVLDTHYSTENDVETIRASVCAPCHASCATCQGPALTDCL
SCPSHASLDPVEQTCSRQSQSSRESPPQQQPPRLPPEVEAGQRLRAGLLPSHLPEVVAGL
SCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEEDEG
RGERTAFIKDQSAL
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| BDBM50552675 |
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| n/a |
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| Name | BDBM50552675 |
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| Synonyms: | CHEMBL4747919 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H53N11O5 |
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| Mol. Mass. | 695.8553 |
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| SMILES | CC(C)(C)[C@H](NC(=O)[C@H](CCONC(N)=N)NC(=O)Cc1ccc(CN)cc1)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N |r| |
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| Structure | 
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