| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 9 |
|---|
| Ligand | BDBM162846 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2035432 (CHEMBL4689590) |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Stott, AJ; Maillard, MC; Beaumont, V; Allcock, D; Aziz, O; Borchers, AH; Blackaby, W; Breccia, P; Creighton-Gutteridge, G; Haughan, AF; Jarvis, RE; Luckhurst, CA; Matthews, KL; McAllister, G; Pollack, S; Saville-Stones, E; Van de Poël, AJ; Vater, HD; Vann, J; Williams, R; Yates, D; Muñoz-Sanjuán, I; Dominguez, C Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. ACS Med Chem Lett12:380-388 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 9 |
|---|
| Name: | Histone deacetylase 9 |
|---|
| Synonyms: | HD9 | HDAC7 | HDAC7B | HDAC9 | HDAC9_HUMAN | HDRP | Histone acetylase 9 (HDAC9) | Histone deacetylase 7B | Histone deacetylase 9 (HDAC9) | Histone deacetylase-related protein | Human HDAC9 | KIAA0744 | MITR |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 111304.31 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9UKV0 |
|---|
| Residue: | 1011 |
|---|
| Sequence: | MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAA
HHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
PLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHA
EQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQ
GVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHP
QSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQ
QIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLG
QVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGL
EKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGR
IQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGD
DSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPP
GHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYI
SLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAK
EFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTA
ICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS
|
|
|
|---|
| BDBM162846 |
|---|
| n/a |
|---|
| Name | BDBM162846 |
|---|
| Synonyms: | US9056843, 137 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H25F3N4O2 |
|---|
| Mol. Mass. | 398.4226 |
|---|
| SMILES | CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
