| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 4 |
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| Ligand | BDBM162846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2035444 (CHEMBL4689602) |
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| Kd | 44±n/a nM |
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| Citation |  Stott, AJ; Maillard, MC; Beaumont, V; Allcock, D; Aziz, O; Borchers, AH; Blackaby, W; Breccia, P; Creighton-Gutteridge, G; Haughan, AF; Jarvis, RE; Luckhurst, CA; Matthews, KL; McAllister, G; Pollack, S; Saville-Stones, E; Van de Poël, AJ; Vater, HD; Vann, J; Williams, R; Yates, D; Muñoz-Sanjuán, I; Dominguez, C Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. ACS Med Chem Lett12:380-388 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 4 |
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| Name: | Histone deacetylase 4 |
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| Synonyms: | Cereblon/Histone deacetylase 4 | HD4 | HDAC4 | HDAC4_HUMAN | Histone acetylase 4(HDAC4) | Human HDAC4 | KIAA0288 |
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| Type: | Enzyme |
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| Mol. Mass.: | 119049.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P56524 |
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| Residue: | 1084 |
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| Sequence: | MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLP
VAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLA
MKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVL
NKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFP
LRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGP
SSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPA
TGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLL
EQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHL
VIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPY
LDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQ
RIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDT
LMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHT
LLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVE
LVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWD
VHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDP
PMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQL
MGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKV
MEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEE
EPPL
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| BDBM162846 |
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| n/a |
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| Name | BDBM162846 |
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| Synonyms: | US9056843, 137 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25F3N4O2 |
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| Mol. Mass. | 398.4226 |
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| SMILES | CCCN(CCC)C[C@@H](C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r| |
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| Structure | 
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