Reaction Details |
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Target | Dipeptidyl peptidase 4 |
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Ligand | BDBM11113 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53366 (CHEMBL666612) |
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IC50 | 110000±n/a nM |
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Citation | Villhauer, EB; Brinkman, JA; Naderi, GB; Dunning, BE; Mangold, BL; Mone, MD; Russell, ME; Weldon, SC; Hughes, TE 1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem45:2362-5 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dipeptidyl peptidase 4 |
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Name: | Dipeptidyl peptidase 4 |
Synonyms: | ACT3 | ADCP-I | Activation molecule 3 | Adenosine deaminase complexing protein | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_BOVIN | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | T-cell activation antigen CD26 | WC10 |
Type: | PROTEIN |
Mol. Mass.: | 88365.89 |
Organism: | Bos taurus |
Description: | ChEMBL_849436 |
Residue: | 765 |
Sequence: | MKTPWKVLLGLLAIAALVTVITVPVVLLTKGNDASTDSRRTYTLADYLKNTFRMKFYNLR
WVSDHEYLYKQENNILLFNAEYGNSSIFLENSTFDEFGHSINDYSVSPDRQYILFEYNYV
KQWRHSYTASYDIYDLNKRQLITEERIPNNTQWITWSSVGHKLAYVWNNDIYVKNEPNSP
SQRITWTGKKDVIYNGITDWVYEEEVFSAYSALWWSPNSTFLAYAQFNDTEVPLIEYSFY
SDESLQYPKTVKIPYPKAGAVNPTIKFFVVNISSLSPNINATSQQIVPPGSVLIGDHYLC
DVTWVTEERISLQWLRRIQNYSIMDICDYDRSTGRWISSVGRQHIEISTTGWVGRFRPAE
PHFTSDGNSFYKIISNEEGYKHICHFQTDKRNCTFITKGAWEVIGIEALTSDYLYYISNE
YKGMPGARNLYKIQLNDYTKVTCLSCELNPDRCQYYSVSFSQEAKYYQLRCSGPGLPLYT
LHNSNNDKELRVLENNSDLDQVLQDVQMPSKKLDFIHLHGTKFWYQMILPPHFDKSKKYP
LLLEVYAGPCSQKADAIFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTF
EVEDQIEATRQFSKMGFVDDKRIAIWGWSYGGYVTSMVLGAGSGVFKCGIAVAPVSKWEY
YDSVYTERYMGLPTPEDNLDSYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISK
ALVDAGVDFQSMWYTDEDHGIASSTAHQHIYTHMSHFLKQCFSLL
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BDBM11113 |
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n/a |
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Name | BDBM11113 |
Synonyms: | 6-{[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)ethyl]amino}pyridine-3-carbonitrile | BMCL15687 Compound 2 | CHEMBL77538 | NVP-DPP728 | cyano-(S)-pyrrolidine deriv. 1 | cyanopyrrolidine derivative 2 |
Type | Small organic molecule |
Emp. Form. | C15H18N6O |
Mol. Mass. | 298.343 |
SMILES | O=C(CNCCNc1ccc(cn1)C#N)N1CCC[C@H]1C#N |r| |
Structure |
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