| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 9 |
|---|
| Ligand | BDBM167699 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2046743 (CHEMBL4701442) |
|---|
| IC50 | 1.2±n/a nM |
|---|
| Citation |  Wu, T; Qin, Z; Tian, Y; Wang, J; Xu, C; Li, Z; Bian, J Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update. J Med Chem63:13228-13257 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 9 |
|---|
| Name: | Cyclin-dependent kinase 9 |
|---|
| Synonyms: | C-2K | CDC2L4 | CDK9 | CDK9_HUMAN | Cell division cycle 2-like protein kinase 4 | Cell division protein kinase 9 | Cyclin-Dependent Kinase 9 (CDK9) | Cyclin-dependent kinase 9 (CDK9) | Serine/threonine-protein kinase PITALRE | TAK | Tat-associated kinase complex catalytic subunit |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 42789.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 372 |
|---|
| Sequence: | MAKQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP
ITALREIKILQLLKHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK
FTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNS
QPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLAL
ISQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDP
AQRIDSDDALNHDFFWSDPMPSDLKGMLSTHLTSMFEYLAPPRRKGSQITQQSTNQSRNP
ATTNQTEFERVF
|
|
|
|---|
| BDBM167699 |
|---|
| n/a |
|---|
| Name | BDBM167699 |
|---|
| Synonyms: | US9073922, 186 | US9796708, Example 186 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H24FN3O3 |
|---|
| Mol. Mass. | 397.4427 |
|---|
| SMILES | COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC(O)CO)CC1 |t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
