| Reaction Details |
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 | Report a problem with these data |
| Target | Calpain-1 catalytic subunit |
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| Ligand | BDBM50114339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_139012 |
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| IC50 | 6200±n/a nM |
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| Citation |  Nakamura, M; Inoue, J Exploration of peptidyl hydrazones as water-soluble calpain inhibitors. Bioorg Med Chem Lett12:1603-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Calpain-1 catalytic subunit |
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| Name: | Calpain-1 catalytic subunit |
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| Synonyms: | CAN1_PIG | CANP 1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain 1 | Calpain mu-type | Calpain-1 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Micromolar-calpain | muCANP |
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| Type: | Catalytic subunit; forms a heterodimer with a small (regulatory) subunit (CAPNS1) |
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| Mol. Mass.: | 81729.82 |
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| Organism: | Sus scrofa (pig) |
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| Description: | Native calpain-1 from porcine erythrocytes, purchased from Calbiochem, was used in assay. |
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| Residue: | 714 |
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| Sequence: | MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEA
FPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILK
ALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKS
QRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSF
VLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSE
EEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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| BDBM50114339 |
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| n/a |
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| Name | BDBM50114339 |
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| Synonyms: | (S)-2-(4-Fluoro-benzenesulfonylamino)-3-methyl-N-{2-[(E)-morpholin-4-ylimino]-ethyl}-butyramide | CHEMBL39287 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25FN4O4S |
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| Mol. Mass. | 400.468 |
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| SMILES | CC(C)[C@H](NS(=O)(=O)c1ccc(F)cc1)C(=O)NCC=NN1CCOCC1 |w:20.21| |
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| Structure | 
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