Reaction Details |
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Target | Calpain-1 catalytic subunit |
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Ligand | BDBM50114342 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_139012 |
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IC50 | 370±n/a nM |
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Citation | Nakamura, M; Inoue, J Exploration of peptidyl hydrazones as water-soluble calpain inhibitors. Bioorg Med Chem Lett12:1603-6 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Calpain-1 catalytic subunit |
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Name: | Calpain-1 catalytic subunit |
Synonyms: | CAN1_PIG | CANP 1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain 1 | Calpain mu-type | Calpain-1 | Calpain-1 catalytic subunit | Calpain-1 large subunit | Micromolar-calpain | muCANP |
Type: | Catalytic subunit; forms a heterodimer with a small (regulatory) subunit (CAPNS1) |
Mol. Mass.: | 81729.82 |
Organism: | Sus scrofa (pig) |
Description: | Native calpain-1 from porcine erythrocytes, purchased from Calbiochem, was used in assay. |
Residue: | 714 |
Sequence: | MAEEVITPVYCTGVSAQVQKLRAKELGLGRHENAIKYLGQDYEQLRAHCLQSGSLFRDEA
FPPVPQSLGFKELGPNSSKTYGVKWKRPTELFSNPQFIVDGATRTDICQGALGDCWLLAA
IASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHS
AQGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYSIILK
ALERGSLLGCSIDISSVLDMEAVTFKKLVKGHAYSVTGAKQVNYQGQMVNLIRMRNPWGE
VEWTGAWSDGSSEWNGVDPYQRDQLRVRMEDGEFWMSFRDFLREFTRLEICNLTPDALKS
QRVRNWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEETDDPEDDYGGRESGCSF
VLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPVHLKRDFFLANASRARSEQFINL
REVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKKAGTQELDDQVQAILPDEQVLSE
EEIDENFKALFRQLAGEDMEISVRELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRD
GNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLFELII
TRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
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BDBM50114342 |
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n/a |
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Name | BDBM50114342 |
Synonyms: | (E)-2-(dimethylamino)-N'-((S)-2-((S)-2-(4-fluorophenylsulfonamido)-3-methylbutanamido)-4-methylpentylidene)acetohydrazide | (S)-N-{(S)-1-[(2-Dimethylamino-acetyl)-hydrazonomethyl]-3-methyl-butyl}-2-(4-fluoro-benzenesulfonylamino)-3-methyl-butyramide | CHEMBL288882 |
Type | Small organic molecule |
Emp. Form. | C21H34FN5O4S |
Mol. Mass. | 471.589 |
SMILES | CC(C)C[C@H](NC(=O)[C@@H](NS(=O)(=O)c1ccc(F)cc1)C(C)C)C=NNC(=O)CN(C)C |w:24.25| |
Structure |
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