| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM50554026 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2048374 (CHEMBL4703073) |
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| IC50 | 0.120000±n/a nM |
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| Citation |  DeRatt, LG; Christine Pietsch, E; Tanner, A; Shaffer, P; Jacoby, E; Wang, W; Kazmi, F; Zhang, X; Attar, RM; Edwards, JP; Kuduk, SD A carboxylic acid isostere screen of the DHODH inhibitor Brequinar. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 42881.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q02127 |
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| Residue: | 395 |
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| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
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| BDBM50554026 |
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| n/a |
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| Name | BDBM50554026 |
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| Synonyms: | CHEMBL4744558 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18F2N2O2 |
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| Mol. Mass. | 404.4087 |
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| SMILES | CONC(=O)c1c(C)c(nc2ccc(F)cc12)-c1ccc(cc1)-c1ccccc1F |
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| Structure | 
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