Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50114468 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_48983 |
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IC50 | 226±n/a nM |
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Citation | Zhang, P; Zuckett, JF; Woolfrey, J; Tran, K; Huang, B; Wong, P; Sinha, U; Park, G; Reed, A; Malinowski, J; Hollenbach, S; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors. Bioorg Med Chem Lett12:1657-61 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50114468 |
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n/a |
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Name | BDBM50114468 |
Synonyms: | 2-{2-[1-(1-Amino-isoquinolin-7-yloxymethyl)-2-phenyl-ethyl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}-benzenesulfonamide | CHEMBL296345 |
Type | Small organic molecule |
Emp. Form. | C32H28N4O4S |
Mol. Mass. | 564.654 |
SMILES | Nc1nccc2ccc(OCC(Cc3ccccc3)N3Cc4cc(ccc4C3=O)-c3ccccc3S(N)(=O)=O)cc12 |
Structure |
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