| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM50114502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_206310 |
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| IC50 | 4200±n/a nM |
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| Citation |  Buynak, JD; Vogeti, L; Doppalapudi, VR; Solomon, GM; Chen, H Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent. Bioorg Med Chem Lett12:1663-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC |
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| Type: | Protien |
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| Mol. Mass.: | 41561.62 |
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| Organism: | Escherichia coli |
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| Description: | P00811 |
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| Residue: | 377 |
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| Sequence: | MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWG
YADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGI
TLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVK
PSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVK
STIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSII
NGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNY
PNPARVDAAWQILNALQ
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|
|
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| BDBM50114502 |
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| n/a |
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| Name | BDBM50114502 |
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| Synonyms: | CHEMBL44588 | Disodium; (R)-5,5,8-trioxo-3-[(E)-2-(2-oxo-propylcarbamoyl)-vinyl]-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13N3O8S |
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| Mol. Mass. | 431.377 |
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| SMILES | [O-]C(=O)CNC(=O)\C=C\C1=C(N2[C@@H](\C(=C/c3ccccn3)C2=O)S(=O)(=O)C1)C([O-])=O |t:9| |
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| Structure | 
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