| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-lactamase |
|---|
| Ligand | BDBM50114514 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_206310 |
|---|
| IC50 | 8.3±n/a nM |
|---|
| Citation |  Buynak, JD; Vogeti, L; Doppalapudi, VR; Solomon, GM; Chen, H Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent. Bioorg Med Chem Lett12:1663-6 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-lactamase |
|---|
| Name: | Beta-lactamase |
|---|
| Synonyms: | AMPC_ECOLI | Beta-lactamase | Beta-lactamase (AmpC) | Beta-lactamase AmpC | Cephalosporinase | Escherichia coli K-12 | ampA | ampC |
|---|
| Type: | Protien |
|---|
| Mol. Mass.: | 41561.62 |
|---|
| Organism: | Escherichia coli |
|---|
| Description: | P00811 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MFKTTLCALLITASCSTFAAPQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTWG
YADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEIKLSDPTTKYWPELTAKQWNGI
TLLHLATYTAGGLPLQVPDEVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAVK
PSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGYREGKAVHVSPGALDAEAYGVK
STIEDMARWVQSNLKPLDINEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSII
NGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFGSYVAFIPEKELGIVMLANKNY
PNPARVDAAWQILNALQ
|
|
|
|---|
| BDBM50114514 |
|---|
| n/a |
|---|
| Name | BDBM50114514 |
|---|
| Synonyms: | CHEMBL44932 | Sodium; (R)-3-[(E)-2-(2-guanidino-ethylcarbamoyl)-vinyl]-5,5,8-trioxo-7-[1-pyridin-2-yl-meth-(Z)-ylidene]-5lambda*6*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19N6O6S |
|---|
| Mol. Mass. | 459.456 |
|---|
| SMILES | NC(=N)NCCNC(=O)C=CC1=C(N2[C@@H](C(=Cc3ccccn3)C2=O)S(=O)(=O)C1)C([O-])=O |w:9.8,16.16,t:11| |
|---|
| Structure | 
|
|---|
Search and Browse
