Reaction Details |
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Target | Melatonin receptor type 1A |
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Ligand | BDBM50114707 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105099 (CHEMBL714106) |
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Ki | 3.51±n/a nM |
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Citation | Wallez, V; Durieux-Poissonnier, S; Chavatte, P; Boutin, JA; Audinot, V; Nicolas, JP; Bennejean, C; Delagrange, P; Renard, P; Lesieur, D Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands. J Med Chem45:2788-800 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Melatonin receptor type 1A |
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Name: | Melatonin receptor type 1A |
Synonyms: | MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A |
Type: | Enzyme |
Mol. Mass.: | 39392.94 |
Organism: | Homo sapiens (Human) |
Description: | P48039 |
Residue: | 350 |
Sequence: | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
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BDBM50114707 |
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n/a |
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Name | BDBM50114707 |
Synonyms: | But-3-enoic acid [2-(2-benzyl-5-methoxy-benzofuran-3-yl)-ethyl]-amide | CHEMBL97186 |
Type | Small organic molecule |
Emp. Form. | C22H23NO3 |
Mol. Mass. | 349.4229 |
SMILES | COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CC=C)c2c1 |
Structure |
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