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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM50114961 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEBML_205711 | ||
| Ki | 4000±n/a nM | ||
| Citation |  Cooper, LC; Carlson, EJ; Castro, JL; Chicchi, GG; Dinnell, K; Di Salvo, J; Elliott, JM; Hollingworth, GJ; Kurtz, MM; Ridgill, MP; Rycroft, W; Tsao, KL; Swain, CJ 4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II. Bioorg Med Chem Lett12:1759-62 (2002) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
| ||
| BDBM50114961 | |||
| n/a | |||
| Name | BDBM50114961 | ||
| Synonyms: | 2-(3,5-Bis-trifluoromethyl-phenyl)-N-[4-(4-oxo-piperidin-1-yl)-1-phenyl-cyclohexyl]-propionamide | CHEMBL431732 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H30F6N2O2 | ||
| Mol. Mass. | 540.5404 | ||
| SMILES | CC(C(=O)N[C@]1(CC[C@@H](CC1)N1CCC(=O)CC1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |wU:5.4,wD:8.11,(12.6,.58,;13.37,-.76,;12.62,-2.07,;13.24,-3.48,;11.08,-1.74,;9.74,-3.17,;11.05,-3.95,;11.05,-5.49,;9.74,-6.24,;8.42,-5.49,;8.42,-3.95,;9.74,-7.77,;8.4,-8.52,;8.4,-10.06,;9.73,-10.82,;9.72,-12.36,;11.05,-10.07,;11.05,-8.52,;8.89,-1.86,;9.6,-.48,;8.73,.84,;7.18,.75,;6.46,-.66,;7.33,-1.95,;14.9,-.76,;16.21,.02,;17.55,-.76,;17.55,-2.3,;16.21,-3.06,;14.9,-2.3,;16.21,-4.6,;14.9,-5.36,;17.55,-5.36,;14.74,-4.21,;18.88,.02,;20.2,-.73,;18.86,1.55,;19.26,-1.46,)| | ||
| Structure | 
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