| Reaction Details |
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 | Report a problem with these data |
| Target | Macrophage metalloelastase |
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| Ligand | BDBM50554437 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2049786 (CHEMBL4704485) |
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| IC50 | 19±n/a nM |
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| Citation |  Baggio, C; Velazquez, JV; Fragai, M; Nordgren, TM; Pellecchia, M Therapeutic Targeting of MMP-12 for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem63:12911-12920 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Macrophage metalloelastase |
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| Name: | Macrophage metalloelastase |
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| Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54012.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P39900 |
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| Residue: | 470 |
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| Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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| BDBM50554437 |
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| n/a |
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| Name | BDBM50554437 |
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| Synonyms: | CHEMBL4764498 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N2O7S |
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| Mol. Mass. | 420.436 |
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| SMILES | COC(=O)Nc1ccc2oc3cc(ccc3c2c1)S(=O)(=O)N[C@H](C(C)C)C(O)=O |r| |
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| Structure | 
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