| Reaction Details |
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 | Report a problem with these data |
| Target | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Ligand | BDBM355878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2051223 (CHEMBL4705922) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Quancard, J; Simic, O; Pissot Soldermann, C; Aichholz, R; Blatter, M; Renatus, M; Erbel, P; Melkko, S; Endres, R; Sorge, M; Kieffer, L; Wagner, T; Beltz, K; Mcsheehy, P; Wartmann, M; Régnier, CH; Calzascia, T; Radimerski, T; Bigaud, M; Weiss, A; Bornancin, F; Schlapbach, A Optimization of the J Med Chem63:14594-14608 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Name: | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 |
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| Synonyms: | MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase |
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| Type: | Enzyme |
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| Mol. Mass.: | 92257.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UDY8 |
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| Residue: | 824 |
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| Sequence: | MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
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| BDBM355878 |
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| n/a |
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| Name | BDBM355878 |
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| Synonyms: | (S)-1-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)-3-(2-(trifluoromethyl)pyridin-4-yl)urea | US10442808, Example 2 | US9815842, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClF3N6O2 |
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| Mol. Mass. | 414.77 |
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| SMILES | CO[C@@H](C)c1c(NC(=O)Nc2ccnc(c2)C(F)(F)F)cnc2cc(Cl)nn12 |r| |
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| Structure | 
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