| Reaction Details |
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 | Report a problem with these data |
| Target | Inward rectifier potassium channel 2 |
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| Ligand | BDBM328993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2051989 (CHEMBL4706990) |
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| IC50 | >10000±n/a nM |
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| Citation |  Osborne, JD; Matthews, TP; McHardy, T; Proisy, N; Cheung, KM; Lainchbury, M; Brown, N; Walton, MI; Eve, PD; Boxall, KJ; Hayes, A; Henley, AT; Valenti, MR; De Haven Brandon, AK; Box, G; Jamin, Y; Robinson, SP; Westwood, IM; van Montfort, RL; Leonard, PM; Lamers, MB; Reader, JC; Aherne, GW; Raynaud, FI; Eccles, SA; Garrett, MD; Collins, I Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737). J Med Chem59:5221-37 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Inward rectifier potassium channel 2 |
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| Name: | Inward rectifier potassium channel 2 |
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| Synonyms: | Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48281.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1515520 |
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| Residue: | 427 |
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| Sequence: | MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN
VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGK
ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVM
AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG
EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG
MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD
LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP
LRRESEI
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| BDBM328993 |
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| n/a |
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| Name | BDBM328993 |
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| Synonyms: | 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile | US11787792, Compound 1 | US9663503, Compound 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16F3N7O |
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| Mol. Mass. | 379.3397 |
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| SMILES | FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1 |r| |
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| Structure | 
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