| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50116728 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_209036 |
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| Ki | 3.6±n/a nM |
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| Citation |  Reichard, GA; Grice, CA; Shih, NY; Spitler, J; Majmundar, S; Wang, SD; Paliwal, S; Anthes, JC; Piwinski, JJ Preparation of oxime dual NK(1)/NK(2) antagonists with reduced NK(3) affinity. Bioorg Med Chem Lett12:2355-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3 |
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| Type: | Protein |
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| Mol. Mass.: | 44455.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21452 |
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| Residue: | 398 |
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| Sequence: | MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
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| BDBM50116728 |
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| n/a |
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| Name | BDBM50116728 |
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| Synonyms: | 3,5-Dichloro-N-{(R)-3-(3,4-dichloro-phenyl)-5-[4-(3-ethylcarbamoylmethyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-piperidin-1-yl]-2-[(Z)-methoxyimino]-pentyl}-N-ethyl-benzamide | CHEMBL430609 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H42Cl4N6O4 |
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| Mol. Mass. | 776.579 |
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| SMILES | CCNC(=O)Cn1c2ccccc2n(C2CCN(CC[C@@H](\C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N\OC)c3ccc(Cl)c(Cl)c3)CC2)c1=O |
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| Structure | 
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