| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM50556299 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2055841 (CHEMBL4710842) |
|---|
| IC50 | 435±n/a nM |
|---|
| Citation |  Abdullaha, M; Nuthakki, VK; Bharate, SB Discovery of methoxy-naphthyl linked N-(1-benzylpiperidine) benzamide as a blood-brain permeable dual inhibitor of acetylcholinesterase and butyrylcholinesterase. Eur J Med Chem207:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 71812.79 |
|---|
| Organism: | Electrophorus electricus (Electric eel) |
|---|
| Description: | n/a |
|---|
| Residue: | 633 |
|---|
| Sequence: | MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFA
EPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLY
LNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGF
LALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDS
RPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLI
DQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYG
APGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIV
GDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHR
ASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINV
DGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAE
RQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
|
|
|
|---|
| BDBM50556299 |
|---|
| n/a |
|---|
| Name | BDBM50556299 |
|---|
| Synonyms: | CHEMBL4777643 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H23BrN2O2 |
|---|
| Mol. Mass. | 463.366 |
|---|
| SMILES | [Br-].COc1ccc2cc(ccc2c1)C(=O)Nc1cc[n+](Cc2ccccc2C)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
