Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50117118 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1316 (CHEMBL616693) |
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Ki | 182±n/a nM |
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Citation | Betti, L; Botta, M; Corelli, F; Floridi, M; Giannaccini, G; Maccari, L; Manetti, F; Strappaghetti, G; Tafi, A; Corsano, S Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives. J Med Chem45:3603-11 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50117118 |
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n/a |
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Name | BDBM50117118 |
Synonyms: | 6-(1H-benzo[d]imidazol-1-yl)-2-(7-(4-(2-chlorophenyl)piperazin-1-yl)heptyl)pyridazin-3(2H)-one | 6-Benzoimidazol-1-yl-2-{7-[4-(2-chloro-phenyl)-piperazin-1-yl]-heptyl}-2H-pyridazin-3-one | CHEMBL420544 |
Type | Small organic molecule |
Emp. Form. | C28H33ClN6O |
Mol. Mass. | 505.054 |
SMILES | Clc1ccccc1N1CCN(CCCCCCCn2nc(ccc2=O)-n2cnc3ccccc23)CC1 |
Structure |
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