| Reaction Details |
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 | Report a problem with these data |
| Target | Discoidin domain-containing receptor 2 |
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| Ligand | BDBM50556597 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2056717 (CHEMBL4711718) |
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| Kd | 40±n/a nM |
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| Citation |  Röhm, S; Schröder, M; Dwyer, JE; Widdowson, CS; Chaikuad, A; Berger, BT; Joerger, AC; Krämer, A; Harbig, J; Dauch, D; Kudolo, M; Laufer, S; Bagley, MC; Knapp, S Selective targeting of the ?C and DFG-out pocket in p38 MAPK. Eur J Med Chem208:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Discoidin domain-containing receptor 2 |
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| Name: | Discoidin domain-containing receptor 2 |
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| Synonyms: | DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10 |
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| Type: | Protein |
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| Mol. Mass.: | 96717.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16832 |
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| Residue: | 855 |
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| Sequence: | MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE
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| BDBM50556597 |
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| n/a |
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| Name | BDBM50556597 |
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| Synonyms: | CHEMBL4756586 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H38N6O3 |
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| Mol. Mass. | 530.6611 |
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| SMILES | CCNC(=O)[C@H](CCC1CCCCC1)NC(=O)c1ccc(CNC(=O)c2cnn(c2N)-c2ccccc2)cc1 |r| |
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| Structure | 
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