Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50171206 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2056745 (CHEMBL4711746) |
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Ki | 56±n/a nM |
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Citation | Abdelrahman, MA; Ibrahim, HS; Nocentini, A; Eldehna, WM; Bonardi, A; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis. Eur J Med Chem209:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50171206 |
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n/a |
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Name | BDBM50171206 |
Synonyms: | CHEMBL3805919 |
Type | Small organic molecule |
Emp. Form. | C17H14BrN3O4S |
Mol. Mass. | 436.28 |
SMILES | C\C(=N/Nc1ccc(cc1)S(N)(=O)=O)c1cc2cc(Br)ccc2oc1=O |
Structure |
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