| Reaction Details |
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 | Report a problem with these data |
| Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Ligand | BDBM50118594 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212264 (CHEMBL816289) |
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| IC50 | 27000±n/a nM |
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| Citation |  Pirrung, MC; Tumey, LN; Raetz, CR; Jackman, JE; Snehalatha, K; McClerren, AL; Fierke, CA; Gantt, SL; Rusche, KM Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. J Med Chem45:4359-70 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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| Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
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| Type: | Enzyme |
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| Mol. Mass.: | 33952.00 |
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| Organism: | Escherichia coli |
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| Description: | P0A725 |
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| Residue: | 305 |
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| Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
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| BDBM50118594 |
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| n/a |
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| Name | BDBM50118594 |
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| Synonyms: | (R/S)-2-Mercapto-1-[3-(4-methoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-ethanone | CHEMBL134636 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13NO3S |
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| Mol. Mass. | 251.302 |
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| SMILES | COc1ccc(cc1)C1=NOC(C1)C(=O)CS |t:9| |
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| Structure | 
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