| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium channel subfamily T member 1 |
|---|
| Ligand | BDBM50557676 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2059777 (CHEMBL4714778) |
|---|
| IC50 | 16±n/a nM |
|---|
| Citation |  Griffin, AM; Kahlig, KM; Hatch, RJ; Hughes, ZA; Chapman, ML; Antonio, B; Marron, BE; Wittmann, M; Martinez-Botella, G Discovery of the First Orally Available, Selective K ACS Med Chem Lett12:593-602 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium channel subfamily T member 1 |
|---|
| Name: | Potassium channel subfamily T member 1 |
|---|
| Synonyms: | KCNT1 | KCNT1_HUMAN | KCa4.1 | KIAA1422 | Potassium channel subfamily T member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 138357.73 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_120153 |
|---|
| Residue: | 1230 |
|---|
| Sequence: | MARAKLPRSPSEGKAGPGGAPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRLPVEDFSL
DSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDDP
ALGIGCWGCPKQNYSFNDSSSEINWAPILWVERKMTLWAIQVIVAIISFLETMLLIYLSY
KGNIWEQIFRVSFVLEMINTLPFIITIFWPPLRNLFIPVFLNCWLAKHALENMINDFHRA
ILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGENLSLLTSFYFCIVTFSTVGYGD
VTPKIWPSQLLVVIMICVALVVLPLQFEELVYLWMERQKSGGNYSRHRAQTEKHVVLCVS
SLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPLWSQRVIYLQGSALKD
QDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFH
VKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRMYGRCSGN
EVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREDNKSILLNPGPRHILAAS
DTCFYINITKEENSAFIFKQEEKRKKRAFSGQGLHEGPARLPVHSIIASMGTVAMDLQGT
EHRPTQSGGGGGGSKLALPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPS
DDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFK
NKLIIVSAETAGNGLYNFIVPLRAYYRSRKELNPIVLLLDNKPDHHFLEAICCFPMVYYM
EGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITT
ELTHPSNMRFMQFRAKDSYSLALSKLEKRERENGSNLAFMFRLPFAAGRVFSISMLDTLL
YQSFVKDYMITITRLLLGLDTTPGSGYLCAMKITEGDLWIRTYGRLFQKLCSSSAEIPIG
IYRTESHVFSTSESQISVNVEDCEDTREVKGPWGSRAGTGGSSQGRHTGGGDPAEHPLLR
RKSLQWARRLSRKAPKQAGRAAAAEWISQQRLSLYRRSERQELSELVKNRMKHLGLPTTG
YEDVANLTASDVMNRVNLGYLQDEMNDHQNTLSYVLINPPPDTRLEPSDIVYLIRSDPLA
HVASSSQSRKSSCSHKLSSCNPETRDETQL
|
|
|
|---|
| BDBM50557676 |
|---|
| n/a |
|---|
| Name | BDBM50557676 |
|---|
| Synonyms: | CHEMBL4763955 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H17F3N6O2 |
|---|
| Mol. Mass. | 406.3618 |
|---|
| SMILES | C[C@H](NC(=O)c1cc(nn1C)C(F)(F)F)c1nc(no1)-c1ccnc(c1)C1CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
