Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetInosine-5'-monophosphate dehydrogenase 2
LigandBDBM50119017
Substrate/Competitorn/a
Meas. Tech.ChEBML_88710
IC50 57.0±n/a nM
Citation Watterson, SH; Liu, C; Dhar, TG; Gu, HH; Pitts, WJ; Barrish, JC; Fleener, CA; Rouleau, K; Sherbina, NZ; Hollenbaugh, DL; Iwanowicz, EJ Novel amide-based inhibitors of inosine 5'-monophosphate dehydrogenase. Bioorg Med Chem Lett12:2879-82 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Inosine-5'-monophosphate dehydrogenase 2
Name:Inosine-5'-monophosphate dehydrogenase 2
Synonyms:IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH)
Type:Enzyme
Mol. Mass.:55806.87
Organism:Homo sapiens (Human)
Description:Recombinant IMPDH2 expressed in E. coli.
Residue:514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50119017
n/a
NameBDBM50119017
Synonyms:(E)-N-(3-Methoxy-4-oxazol-5-yl-phenyl)-3-pyridin-4-yl-acrylamide | CHEMBL98224
TypeSmall organic molecule
Emp. Form.C18H15N3O3
Mol. Mass.321.33
SMILESCOc1cc(NC(=O)\C=C\c2ccncc2)ccc1-c1cnco1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: