| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin B |
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| Ligand | BDBM19807 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_47424 (CHEMBL662611) |
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| Ki | >1000±n/a nM |
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| Citation |  Huang, L; Ellman, JA General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain. Bioorg Med Chem Lett12:2993-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin B |
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| Name: | Cathepsin B |
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| Synonyms: | APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 37819.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_63102437 |
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| Residue: | 339 |
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| Sequence: | MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
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| BDBM19807 |
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| n/a |
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| Name | BDBM19807 |
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| Synonyms: | CHEMBL100563 | benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl]-4-oxopyrrolidin-3-yl}carbamoyl)-3-methylbutyl]carbamate | pyrrolidinone analogue, 24 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H42N4O7 |
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| Mol. Mass. | 594.6985 |
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| SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NC1CN(CC1=O)C(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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