| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM139041 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2060587 (CHEMBL4715588) |
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| Ki | 193±n/a nM |
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| Citation |  Tao, ZF; Wang, X; Chen, J; Ingram, JP; Jin, S; Judge, RA; Kovar, PJ; Park, C; Sun, C; Wakefield, BD; Zhou, L; Zhang, H; Elmore, SW; Phillips, DC; Judd, AS; Leverson, JD; Souers, AJ Structure-Based Design of A-1293102, a Potent and Selective BCL-X ACS Med Chem Lett12:1011-1016 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM139041 |
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| n/a |
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| Name | BDBM139041 |
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| Synonyms: | US8883784, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H40F3N7O7S5 |
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| Mol. Mass. | 972.13 |
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| SMILES | FC(F)(F)S(=O)(=O)c1cc(ccc1N[C@H](CCN1CCOCC1)CSc1ccccc1)S(=O)(=O)NC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 |
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| Structure | 
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