| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50120170 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_205875 |
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| Ki | 136±n/a nM |
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| Citation |  Blythin, DJ; Chen, X; Piwinski, JJ; Shih, NY; Shue, HJ; Anthes, JC; McPhail, AT Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines. Bioorg Med Chem Lett12:3161-5 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50120170 |
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| n/a |
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| Name | BDBM50120170 |
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| Synonyms: | 2-(1-Benzyl-piperidin-4-ylamino)-1-{4-[2-(3,5-bis-trifluoromethyl-phenyl)-acetyl]-2-phenyl-piperazin-1-yl}-ethanone | CHEMBL107309 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H36F6N4O2 |
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| Mol. Mass. | 646.6657 |
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| SMILES | FC(F)(F)c1cc(CC(=O)N2CCN(C(C2)c2ccccc2)C(=O)CNC2CCN(Cc3ccccc3)CC2)cc(c1)C(F)(F)F |
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| Structure | 
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