Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50120692 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_106129 (CHEMBL718677) |
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Ki | 4747±n/a nM |
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Citation | Duan, JJ; Chen, L; Wasserman, ZR; Lu, Z; Liu, RQ; Covington, MB; Qian, M; Hardman, KD; Magolda, RL; Newton, RC; Christ, DD; Wexler, RR; Decicco, CP Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. J Med Chem45:4954-7 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50120692 |
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n/a |
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Name | BDBM50120692 |
Synonyms: | 2-{3-[4-(3,5-Dimethyl-benzyloxy)-phenyl]-3-methyl-2-oxo-pyrrolidin-1-yl}-N-hydroxy-propionamide | CHEMBL144548 |
Type | Small organic molecule |
Emp. Form. | C23H28N2O4 |
Mol. Mass. | 396.4794 |
SMILES | C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(C)cc(C)c2)cc1)C(=O)NO |
Structure |
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