Reaction Details |
| Report a problem with these data |
Target | Interstitial collagenase |
---|
Ligand | BDBM26526 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_106129 (CHEMBL718677) |
---|
Ki | 30000±n/a nM |
---|
Citation | Duan, JJ; Chen, L; Wasserman, ZR; Lu, Z; Liu, RQ; Covington, MB; Qian, M; Hardman, KD; Magolda, RL; Newton, RC; Christ, DD; Wexler, RR; Decicco, CP Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. J Med Chem45:4954-7 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Interstitial collagenase |
---|
Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
|
|
|
BDBM26526 |
---|
n/a |
---|
Name | BDBM26526 |
Synonyms: | (2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide | BMCL181958 Compound 1 | CHEMBL148169 | IK682 |
Type | Small organic molecule |
Emp. Form. | C25H27N3O4 |
Mol. Mass. | 433.4996 |
SMILES | C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO |r| |
Structure |
|