| Reaction Details |
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 | Report a problem with these data |
| Target | Stimulator of interferon genes protein |
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| Ligand | BDBM50506263 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2064380 (CHEMBL4719633) |
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| EC50 | 18800±n/a nM |
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| Citation |  Lioux, T; Mauny, MA; Lamoureux, A; Bascoul, N; Hays, M; Vernejoul, F; Baudru, AS; Boularan, C; Lopes-Vicente, J; Qushair, G; Tiraby, G Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine-Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING). J Med Chem59:10253-10267 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Stimulator of interferon genes protein |
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| Name: | Stimulator of interferon genes protein |
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| Synonyms: | Endoplasmic reticulum interferon stimulator | Eris | MMITA | Mediator of IRF3 activation | Mita | Mpys | STING_MOUSE | Stimulator of interferon genes protein | Sting | Sting1 | Synonyms=Eris | Tmem173 | Transmembrane protein 173 | mSTING |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42834.49 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_119061 |
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| Residue: | 378 |
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| Sequence: | MPYSNLHPAIPRPRGHRSKYVALIFLVASLMILWVAKDPPNHTLKYLALHLASHELGLLL
KNLCCLAEELCHVQSRYQGSYWKAVRACLGCPIHCMAMILLSSYFYFLQNTADIYLSWMF
GLLVLYKSLSMLLGLQSLTPAEVSAVCEEKKLNVAHGLAWSYYIGYLRLILPGLQARIRM
FNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYS
NSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILED
VPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEKEEVTMNAPMTSVAPPPSVLSQEP
RLLISGMDQPLPLRTDLI
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| BDBM50506263 |
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| n/a |
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| Name | BDBM50506263 |
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| Synonyms: | CHEMBL4465054 | US11401295, Compound 2',3'-cGAMP |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N10O13P2 |
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| Mol. Mass. | 674.4113 |
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| SMILES | [H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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