Reaction Details |
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Target | Tripeptidyl-peptidase 2 |
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Ligand | BDBM50121282 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_211946 (CHEMBL816536) |
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IC50 | 7±n/a nM |
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Citation | Breslin, HJ; Miskowski, TA; Kukla, MJ; Leister, WH; De Winter, HL; Gauthier, DA; Somers, MV; Peeters, DC; Roevens, PW Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles. J Med Chem45:5303-10 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tripeptidyl-peptidase 2 |
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Name: | Tripeptidyl-peptidase 2 |
Synonyms: | TPP2_RAT | Tpp2 | Tripeptidyl aminopeptidase |
Type: | PROTEIN |
Mol. Mass.: | 138287.08 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_211948 |
Residue: | 1249 |
Sequence: | MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDG
KPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPANWTNPSGKYHIGIKNGYDF
YPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVEL
LNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAE
MLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTR
LSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSA
GNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGAL
GVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRR
ALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQ
VAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVD
PRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIR
RHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIE
AFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLK
YEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSC
PLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDL
DRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIP
KGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEE
FTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAA
NAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQP
HDGAAAGDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLK
FATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
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BDBM50121282 |
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n/a |
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Name | BDBM50121282 |
Synonyms: | (S)-1-((S)-2-aminobutanoyl)-N-butylindoline-2-carboxamide | 1-(2-Amino-butyryl)-2,3-dihydro-1H-indole-2-carboxylic acid butylamide | CHEMBL151059 |
Type | Small organic molecule |
Emp. Form. | C17H25N3O2 |
Mol. Mass. | 303.3993 |
SMILES | CCCCNC(=O)[C@@H]1Cc2ccccc2N1C(=O)[C@@H](N)CC |
Structure |
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