| Reaction Details |
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 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A/B |
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| Ligand | BDBM50121455 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_122448 (CHEMBL731137) |
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| Ki | 5500±n/a nM |
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| Citation |  Manna, F; Chimenti, F; Bolasco, A; Secci, D; Bizzarri, B; Befani, O; Turini, P; Mondovi, B; Alcaro, S; Tafi, A Inhibition of amine oxidases activity by 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives. Bioorg Med Chem Lett12:3629-33 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Amine oxidase [flavin-containing] A/B |
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| Name: | Amine oxidase [flavin-containing] A/B |
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| Synonyms: | Monoamine oxidase |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1929828 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Amine oxidase [flavin-containing] B |
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| Synonyms: | AOFB_BOVIN | Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B | Monoamine oxidase type B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58428.94 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_1501478 |
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| Residue: | 520 |
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| Sequence: | MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWR
TMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEV
SALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQ
TGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVY
YKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEER
LKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTT
FLQRHLPSVPGLLKLIGLTTIFSATALGFLAHKRGLLVRI
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| Component 2 |
| Name: | Amine oxidase [flavin-containing] A |
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| Synonyms: | AOFA_BOVIN | Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59764.63 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_1501477 |
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| Residue: | 527 |
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| Sequence: | MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
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| BDBM50121455 |
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| n/a |
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| Name | BDBM50121455 |
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| Synonyms: | 1-[3-(2-Hydroxy-phenyl)-5-m-tolyl-4,5-dihydro-pyrazol-1-yl]-ethanone | CHEMBL120717 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N2O2 |
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| Mol. Mass. | 294.3477 |
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| SMILES | CC(=O)N1N=C(CC1c1cccc(C)c1)c1ccccc1O |c:4| |
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| Structure | 
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