Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50122243 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1141 |
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Ki | 0.800000±n/a nM |
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Citation | Betti, L; Floridi, M; Giannaccini, G; Manetti, F; Strappaghetti, G; Tafi, A; Botta, M alpha1-Adrenoceptor antagonists. 5. Pyridazinone-arylpiperazines. Probing the influence on affinity and selectivity of both ortho-alkoxy groups at the arylpiperazine moiety and cyclic substituents at the pyridazinone nucleus. Bioorg Med Chem Lett13:171-3 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50122243 |
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n/a |
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Name | BDBM50122243 |
Synonyms: | 4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2-{7-[4-(2-isopropoxy-phenyl)-piperazin-1-yl]-heptyl}-2H-pyridazin-3-one | 4-chloro-5-(4-(furan-2-carbonyl)piperazin-1-yl)-2-(7-(4-(2-isopropoxyphenyl)piperazin-1-yl)heptyl)pyridazin-3(2H)-one | CHEMBL47792 |
Type | Small organic molecule |
Emp. Form. | C33H45ClN6O4 |
Mol. Mass. | 625.201 |
SMILES | CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1 |
Structure |
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