Reaction Details |
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Target | Tyrosine-protein kinase Blk |
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Ligand | BDBM50559921 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2070675 (CHEMBL4726209) |
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IC50 | 8.3±n/a nM |
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Citation | de Bruin, G; Demont, D; de Zwart, E; Verkaik, S; Hoogenboom, N; van de Kar, B; van Lith, B; Emmelot-van Hoek, M; Gulrajani, M; Covey, T; Kaptein, A; Barf, T Discovery of quinoline-based irreversible BTK inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Blk |
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Name: | Tyrosine-protein kinase Blk |
Synonyms: | B lymphoid tyrosine kinase | BLK | BLK_HUMAN | SRC | Tyrosine-protein kinase BLK (BLK) | p55-Blk |
Type: | Protein |
Mol. Mass.: | 57711.88 |
Organism: | Homo sapiens (Human) |
Description: | P51451 |
Residue: | 505 |
Sequence: | MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDK
HFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLE
MERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIR
CLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQS
LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY
AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD
LRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWS
FGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEER
PTFEFLQSVLEDFYTATERQYELQP
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BDBM50559921 |
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n/a |
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Name | BDBM50559921 |
Synonyms: | CHEMBL4755977 |
Type | Small organic molecule |
Emp. Form. | C31H29N5O5 |
Mol. Mass. | 551.5925 |
SMILES | COc1cc2nccc(Oc3ccc(cc3)C(=O)Nc3ccccn3)c2cc1NC(=O)C#CCCN1CCOCC1 |
Structure |
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