| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metallo-beta-lactamase GIM-1 |
|---|
| Ligand | BDBM50560030 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2071127 (CHEMBL4726661) |
|---|
| IC50 | 227000±n/a nM |
|---|
| Citation |  Muhammad, Z; Skagseth, S; Boomgaren, M; Akhter, S; Fröhlich, C; Ismael, A; Christopeit, T; Bayer, A; Leiros, HS Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-?-lactamases. Bioorg Med Chem28:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metallo-beta-lactamase GIM-1 |
|---|
| Name: | Metallo-beta-lactamase GIM-1 |
|---|
| Synonyms: | GIM-1 | GIM-1 protein | Metallo-beta-lactamase GIM-1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 27418.35 |
|---|
| Organism: | Pseudomonas aeruginosa |
|---|
| Description: | n/a |
|---|
| Residue: | 250 |
|---|
| Sequence: | MKNVLVFLILLVALPALAQGHKPLEVIKIEDGVYLHTSFKNIEGYGLVDSNGLVVLDNNQ
AYIIDTPWSEEDTKLLLSWATDRGYQVMASISTHSHEDRTAGIKLLNSKSIPTYTSELTK
KLLAREGKPVPTHYFKDDEFTLGNGLIELYYPGAGHTEDNIVAWLPKSKILFGGCLVRSH
EWEGLGYVGDASISSWADSIKNIVSKKYPIQMVVPGHGKVGSSDILDHTIDLAESASNKL
MQPTAEASAD
|
|
|
|---|
| BDBM50560030 |
|---|
| n/a |
|---|
| Name | BDBM50560030 |
|---|
| Synonyms: | CHEMBL4760439 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19IN4O3S2 |
|---|
| Mol. Mass. | 530.403 |
|---|
| SMILES | COc1ccc(CSCc2nn[nH]c2CNS(=O)(=O)c2ccc(I)cc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
