| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50122511 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_106341 (CHEMBL713796) |
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| IC50 | >10000±n/a nM |
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| Citation |  Arasasingham, PN; Fotsch, C; Ouyang, X; Norman, MH; Kelly, MG; Stark, KL; Karbon, B; Hale, C; Baumgartner, JW; Zambrano, M; Cheetham, J; Tamayo, NA Structure-activity relationship of (1-aryl-2-piperazinylethyl)piperazines: antagonists for the AGRP/melanocortin receptor binding. J Med Chem46:9-11 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50122511 |
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| n/a |
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| Name | BDBM50122511 |
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| Synonyms: | 2-{4-[2-(4-Chloro-phenyl)-2-(4-methyl-piperazin-1-yl)-ethyl]-piperazin-1-ylmethyl}-3,4-dihydro-2H-naphthalen-1-one | CHEMBL12370 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H37ClN4O |
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| Mol. Mass. | 481.073 |
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| SMILES | CN1CCN(CC1)C(CN1CCN(CC2CCc3ccccc3C2=O)CC1)c1ccc(Cl)cc1 |
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| Structure | 
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