| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Purine nucleoside phosphorylase |
|---|
| Ligand | BDBM50122726 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_162004 (CHEMBL764175) |
|---|
| Ki | 0.023±n/a nM |
|---|
| Citation |  Evans, GB; Furneaux, RH; Gainsford, GJ; Hanson, JC; Kicska, GA; Sauve, AA; Schramm, VL; Tyler, PC 8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases. J Med Chem46:155-60 (2002) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Purine nucleoside phosphorylase |
|---|
| Name: | Purine nucleoside phosphorylase |
|---|
| Synonyms: | Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32035.18 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | n/a |
|---|
| Residue: | 289 |
|---|
| Sequence: | MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
|
|
|
|---|
| BDBM50122726 |
|---|
| n/a |
|---|
| Name | BDBM50122726 |
|---|
| Synonyms: | 2-Hydroxymethyl-5-(4-hydroxy-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-pyrrolidine-3,4-diol | CHEMBL288187 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H14N4O4 |
|---|
| Mol. Mass. | 266.2533 |
|---|
| SMILES | OC[C@H]1NC([C@@H](O)[C@H]1O)c1c[nH]c2c1nc[nH]c2=O |
|---|
| Structure | 
|
|---|
Search and Browse
