| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
|---|
| Ligand | BDBM50123001 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_124499 |
|---|
| IC50 | 990±n/a nM |
|---|
| Citation |  Rupert, KC; Henry, JR; Dodd, JH; Wadsworth, SA; Cavender, DE; Olini, GC; Fahmy, B; Siekierka, JJ Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett13:347-50 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase 14 |
|---|
| Name: | Mitogen-activated protein kinase 14 |
|---|
| Synonyms: | Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41281.22 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography. |
|---|
| Residue: | 360 |
|---|
| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
|
|
|
|---|
| BDBM50123001 |
|---|
| n/a |
|---|
| Name | BDBM50123001 |
|---|
| Synonyms: | 2-Phenyl-3-pyrimidin-4-yl-imidazo[1,2-a]pyrimidin-7-ylamine | 2-phenyl-3-(pyrimidin-4-yl)imidazo[1,2-a]pyrimidin-7-amine | CHEMBL326748 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12N6 |
|---|
| Mol. Mass. | 288.3067 |
|---|
| SMILES | Nc1ccn2c(c(nc2n1)-c1ccccc1)-c1ccncn1 |
|---|
| Structure | 
|
|---|
Search and Browse
