| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fatty-acid amide hydrolase 1 |
|---|
| Ligand | BDBM50560616 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2072576 (CHEMBL4728110) |
|---|
| IC50 | 6.3±n/a nM |
|---|
| Citation |  Keith, JM; Jones, W; Pierce, JM; Seierstad, M; Palmer, JA; Webb, M; Karbarz, M; Scott, BP; Wilson, SJ; Luo, L; Wennerholm, M; Chang, L; Rizzolio, M; Rynberg, R; Chaplan, S; Guy Breitenbucher, J Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fatty-acid amide hydrolase 1 |
|---|
| Name: | Fatty-acid amide hydrolase 1 |
|---|
| Synonyms: | Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63071.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O00519 |
|---|
| Residue: | 579 |
|---|
| Sequence: | MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQ
RFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLAD
CETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAV
PFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGG
SIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCE
DMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTL
VPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAF
LVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALD
LNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMK
KSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
|
|
|
|---|
| BDBM50560616 |
|---|
| n/a |
|---|
| Name | BDBM50560616 |
|---|
| Synonyms: | CHEMBL4755710 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H23ClN4O3 |
|---|
| Mol. Mass. | 438.907 |
|---|
| SMILES | [H][C@@]12CN(Cc3cccc(Oc4ccc(Cl)cc4)c3)C[C@]1([H])CN(C2)C(=O)Nc1ccon1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
