| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK2 |
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| Ligand | BDBM50560704 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2072769 (CHEMBL4728303) |
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| IC50 | 20±n/a nM |
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| Citation |  Schröder, M; Bullock, AN; Fedorov, O; Bracher, F; Chaikuad, A; Knapp, S DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity. J Med Chem63:10224-10234 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK2 |
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| Name: | Dual specificity protein kinase CLK2 |
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| Synonyms: | 2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN |
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| Type: | n/a |
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| Mol. Mass.: | 60128.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49760 |
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| Residue: | 499 |
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| Sequence: | MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYD
DRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRR
RRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQC
VDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMC
ISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVN
SDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQ
PCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLD
WDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFA
RLRAEPPNKLWDSSRDISR
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| BDBM50560704 |
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| n/a |
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| Name | BDBM50560704 |
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| Synonyms: | CHEMBL4754195 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H16N4O |
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| Mol. Mass. | 352.3886 |
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| SMILES | Cn1cc(cn1)-c1ccc2occ(-c3cccc(c3)-c3ccncc3)c2n1 |
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| Structure | 
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