Reaction Details | |||
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Target | Tumor necrosis factor receptor superfamily member 1A | ||
Ligand | BDBM50123286 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_212214 | ||
IC50 | 790.0±n/a nM | ||
Citation | Voss, ME; Carter, PH; Tebben, AJ; Scherle, PA; Brown, GD; Thompson, LA; Xu, M; Lo, YC; Yang, G; Liu, RQ; Strzemienski, P; Everlof, JG; Trzaskos, JM; Decicco, CP Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists. Bioorg Med Chem Lett13:533-8 (2003) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Tumor necrosis factor receptor superfamily member 1A | |||
Name: | Tumor necrosis factor receptor superfamily member 1A | ||
Synonyms: | CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 50495.39 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1509419 | ||
Residue: | 455 | ||
Sequence: |
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BDBM50123286 | |||
n/a | |||
Name | BDBM50123286 | ||
Synonyms: | 5-(1H-Indol-3-ylmethylene)-2-thioxo-1,3-di-o-tolyl-dihydro-pyrimidine-4,6-dione | CHEMBL347715 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H21N3O2S | ||
Mol. Mass. | 451.54 | ||
SMILES | Cc1ccccc1N1C(=S)N(C(=O)C(=Cc2c[nH]c3ccccc23)C1=O)c1ccccc1C |(14.85,3.89,;13.35,3.48,;12.26,4.59,;10.76,4.17,;10.36,2.66,;11.46,1.56,;12.96,1.98,;14.05,.88,;13.72,-.63,;12.26,-1.1,;14.86,-1.66,;16.34,-1.2,;17.48,-2.22,;16.64,.3,;18.11,.79,;19.26,-.26,;19.09,-1.78,;20.49,-2.41,;21.52,-1.27,;23.06,-1.27,;23.83,.06,;23.06,1.39,;21.52,1.39,;20.77,.07,;15.52,1.35,;15.84,2.85,;14.45,-3.15,;12.96,-3.52,;12.55,-5,;13.63,-6.1,;15.12,-5.7,;15.52,-4.23,;17.02,-3.83,)| | ||
Structure |