| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Arginase-1 |
|---|
| Ligand | BDBM50561041 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2074195 (CHEMBL4729729) |
|---|
| IC50 | 1.6±n/a nM |
|---|
| Citation |  Borek, B; Gajda, T; Golebiowski, A; Blaszczyk, R Boronic acid-based arginase inhibitors in cancer immunotherapy. Bioorg Med Chem28:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Arginase-1 |
|---|
| Name: | Arginase-1 |
|---|
| Synonyms: | ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 34737.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_978893 |
|---|
| Residue: | 322 |
|---|
| Sequence: | MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPN
DSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGV
IWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLR
DVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSF
TPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAIT
LACFGLAREGNHKPIDYLNPPK
|
|
|
|---|
| BDBM50561041 |
|---|
| n/a |
|---|
| Name | BDBM50561041 |
|---|
| Synonyms: | CHEMBL4791224 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H28BN3O5 |
|---|
| Mol. Mass. | 329.2 |
|---|
| SMILES | CC(C)C[C@H](N)C(=O)N[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
